Sodium Hydroxide → HCID 11181565, compound

HRID 733617Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:39]=[CH:38][C:13]([CH2:14][N:15]([C:25]3[CH:37]=[CH:36][C:28]4[O:29]C(C)(C)[O:31][C:32](=[O:33])[C:27]=4[CH:26]=3)[C:16](=[O:24])[C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=3)=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:14][N:15]([C:16](=[O:24])[C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=3)[C:25]3[CH:37]=[CH:36][C:28]([OH:29])=[C:27]([CH:26]=3)[C:32]([OH:33])=[O:31])=[CH:38][CH:39]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 57841336HCID 57841336, compound

Product 1

HCID 11181565HCID 11181565, compound

Procedure

The titled compound was prepared following the procedure C using N-{4-[(4-chlorophenyl)ethynyl]benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)-3-fluorobenzamide and NaOH as a white powder (56%). 1H NMR (MeOD, 300 MHz) δ 7.51 (m, 5H), 7.45-7.22 (m, 5H), 7.20-7.02 (m, 4H), 6.79 (d, J=9 Hz, 1H), 5.15 (s, 2H) M− (ESI): 497.9. HPLC. Rt: 4.92 min (Purity: 97.9%).

Sources & evidence

ORD record: ord-77cbacd97329435783b846cecadb33af
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07589232B2

Reaction notes

Loading…