3-Cyclopentylpropionyl chloride → HCID 57841389, compound

HRID 733635Notes

Reaction equation

HRID 733635 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:32]=[CH:31][C:16]([CH2:17][NH:18][C:19]3[CH:20]=[C:21]([CH:27]=[CH:28][C:29]=3[F:30])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[CH:33]1([CH2:38][CH2:39][C:40](Cl)=[O:41])[CH2:37][CH2:36][CH2:35][CH2:34]1>CN(C1C=CN=CC=1)C>[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[C:12][C:13]2[CH:32]=[CH:31][C:16]([CH2:17][N:18]([C:40](=[O:41])[CH2:39][CH2:38][CH:33]3[CH2:37][CH2:36][CH2:35][CH2:34]3)[C:19]3[CH:20]=[C:21]([CH:27]=[CH:28][C:29]=3[F:30])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:15][CH:14]=2)=[CH:9][CH:10]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 660393-Cyclopentylpropionyl chlorideHCID 11189594Ethyl 3-({4-[(4-butylphenyl)ethynyl]benzyl}amino)-4-fluorobenzoate

Product 1

HCID 57841389HCID 57841389, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

The titled compound was prepared following the procedure B using ethyl 3-({4-[(4-butylphenyl)ethynyl]benzyl}amino)-4-fluorobenzoate and 3-cyclopentylpropionyl chloride in the presence of DMAP as a colorless oil (15%). M+ (ESI): 553.9. HPLC, Rt: 6.39 min (Purity: 93.6%).

Sources & evidence

ORD record
ord-87914e62222849de8d105544530e4d7e
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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