3-Cyclopentylpropionyl chloride → N-(4-bromobenzyl)-3-cyclopentyl-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)propanamide

HRID 733646Notes

Reaction equation

HRID 733646 reaction equation
[Br:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][NH:7][C:8]2[CH:9]=[CH:10][C:11]3[C:16](=[O:17])[O:15][C:14]([CH3:19])([CH3:18])[O:13][C:12]=3[CH:20]=2)=[CH:4][CH:3]=1.[CH:23]1([CH2:28][CH2:29][C:30](Cl)=[O:31])[CH2:27][CH2:26][CH2:25][CH2:24]1>>[Br:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][N:7]([C:8]2[CH:9]=[CH:10][C:11]3[C:16](=[O:17])[O:15][C:14]([CH3:19])([CH3:18])[O:13][C:12]=3[CH:20]=2)[C:30](=[O:31])[CH2:29][CH2:28][CH:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 660393-Cyclopentylpropionyl chlorideHCID 578413877-[(4-bromobenzyl)amino]-2,2-dimethyl-4H-1,3-benzodioxin-4-one

Product 1

HCID 57841396N-(4-bromobenzyl)-3-cyclopentyl-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)propanamide

Procedure

The titled compound was prepared following the procedure M using 7-[(4-bromobenzyl)amino]-2,2-dimethyl-4H-1,3-benzodioxin-4-one and 3-cyclopentylpropionyl chloride as a white powder (86%). M+ (ESI): 488.0. HPLC, Rt: 5.41 min (Purity: 99.9%).

Sources & evidence

ORD record
ord-74f919c50ce34e87b1ca7d4aeb793567
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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