4-tert-Butylphenylacetylene → N-{4-[(4-tert-butylphenyl)ethynyl]benzyl}-3-cyclopentyl-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)propanamide

HRID 733647Notes

Reaction equation

HRID 733647 reaction equation
Br[C:2]1[CH:31]=[CH:30][C:5]([CH2:6][N:7]([C:17]2[CH:18]=[CH:19][C:20]3[C:25](=[O:26])[O:24][C:23]([CH3:28])([CH3:27])[O:22][C:21]=3[CH:29]=2)[C:8](=[O:16])[CH2:9][CH2:10][CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:4][CH:3]=1.[C:32]([C:36]1[CH:41]=[CH:40][C:39]([C:42]#[CH:43])=[CH:38][CH:37]=1)([CH3:35])([CH3:34])[CH3:33]>>[C:32]([C:36]1[CH:37]=[CH:38][C:39]([C:42]#[C:43][C:2]2[CH:3]=[CH:4][C:5]([CH2:6][N:7]([C:17]3[CH:18]=[CH:19][C:20]4[C:25](=[O:26])[O:24][C:23]([CH3:27])([CH3:28])[O:22][C:21]=4[CH:29]=3)[C:8](=[O:16])[CH2:9][CH2:10][CH:11]3[CH2:12][CH2:13][CH2:14][CH2:15]3)=[CH:30][CH:31]=2)=[CH:40][CH:41]=1)([CH3:35])([CH3:34])[CH3:33]

Participants

3

Reactant 2

HCID 27573024-tert-ButylphenylacetyleneHCID 57841396N-(4-bromobenzyl)-3-cyclopentyl-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)propanamide

Product 1

HCID 57841343N-{4-[(4-tert-butylphenyl)ethynyl]benzyl}-3-cyclopentyl-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)propanamide

Procedure

The titled compound was prepared following the procedure N using N-(4-bromobenzyl)-3-cyclopentyl-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)propanamide and 4-(tert-butyl)-phenylacetylene as a beige powder (65%). M1(ESI): 564.2. HPLC, Rt: 6.39 min (Purity: 98.9%).

Sources & evidence

ORD record
ord-6ecbaa5497874e98abacc77d3c665988
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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