4-Aminotetrahydropyran → HCID 57840941, compound

HRID 733671Notes

Reaction equation

HRID 733671 reaction equation
[C:1]([O:5][C:6]([N:8]1[C:12]2[C:13]([Cl:20])=[N:14][CH:15]=[C:16]([C:17](O)=[O:18])[C:11]=2[C:10]([CH3:21])=[CH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:22]1[CH2:27][CH2:26][CH:25]([NH2:28])[CH2:24][CH2:23]1>>[C:1]([O:5][C:6]([N:8]1[C:12]2=[C:13]([Cl:20])[N:14]=[CH:15][C:16]([C:17](=[O:18])[NH:28][CH:25]3[CH2:26][CH2:27][O:22][CH2:23][CH2:24]3)=[C:11]2[C:10]([CH3:21])=[CH:9]1)=[O:7])([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 44475513HCID 44475513, compound

Product 1

HCID 57840941HCID 57840941, compound

Procedure

Prepared in a similar manner to Example 11 (b) from 7-chloro-3-methyl-pyrrolo[2,3-c]pyridine-1,4-dicarboxylic acid 1-tert-butyl ester and using tetrahydro-pyran-4-ylamine (195 mg) instead of morpholine. The title compound was further purified by trituration with ether/isohexane to give an off-white solid (324 mg).

Workup

  1. customThe title compound was further purified by trituration with ether/isohexane

Sources & evidence

ORD record
ord-1a5e7d9ede3f4538b3b93ff3a984b4f2
Source dataset
uspto-grants-2009_09
Patent number
US07589206B2

Reaction notes

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