反应详情

温度

180 °C

A mixture of 7-chloro-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid (tetrahydro-pyran-4-ylmethyl)-amide (20 mg), 3-chloroaniline (15 ul), and methanesulfonic acid (9 ul) in 1,4-dioxane (0.5 ml) was heated under microwave conditions at 180° C. for 30 minutes. The solid mass obtained was dissolved in methanol, transferred to a round bottom flask and evaporated. The residue was partitioned between ethyl acetate and 5% sodium hydrogen carbonate solution whereby the title compound remained as a solid at the interface. The solid was filtered off, and washed with 5% sodium hydrogen carbonate solution, water and diethyl ether, then sucked dry and dried at 60° C. under vacuum to afford the title compound (17 mg).

1. customThe solid mass obtained
2. customtransferred to a round bottom flask
3. customevaporated
4. customThe residue was partitioned between ethyl acetate and 5% sodium hydrogen carbonate solution whereby the title compound
5. filtrationThe solid was filtered off
6. washwashed with 5% sodium hydrogen carbonate solution, water and diethyl ether
7. customsucked dry
8. customdried at 60° C. under vacuum