1-Cyclobutylmethanamine hydrochloride → 7-chloro-N-(cyclobutylmethyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxamide

HRID 733681Notes

Reaction equation

HRID 733681 reaction equation
[Cl:1][C:2]1[C:7]2[NH:8][CH:9]=[CH:10][C:6]=2[C:5]([C:11]([OH:13])=O)=[CH:4][N:3]=1.Cl.[CH:15]1([CH2:19][NH2:20])[CH2:18][CH2:17][CH2:16]1>>[CH:15]1([CH2:19][NH:20][C:11]([C:5]2[C:6]3[CH:10]=[CH:9][NH:8][C:7]=3[C:2]([Cl:1])=[N:3][CH:4]=2)=[O:13])[CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 217079441-Cyclobutylmethanamine hydrochlorideHCID 578408437-chloro-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid

Product 1

HCID 578407827-chloro-N-(cyclobutylmethyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxamide

Procedure

Prepared in a similar manner to Example 19 (e) from 7-chloro-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid using cyclobutylmethylamine hydrochloride (46 mg) instead of tetrahydro-pyran-4-ylmethylamine to give the title compound (39 mg).

Sources & evidence

ORD record
ord-8ea13bc326cc4625be04bed8be36d4b7
Source dataset
uspto-grants-2009_09
Patent number
US07589206B2

Reaction notes

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