反应详情

A solution of methyl 2-{2-hydroxy-1-[(methyloxy)carbonyl]ethenyl}-1-methyl-1H-pyrrole-3-carboxylate (65.2 g) and ammonium acetate (105 g) in methanol (800 ml) was heated at reflux for 7 hours. The reaction was cooled and the methanol removed. The residue was partitioned between ethyl acetate and water. Large amounts (>2 L) of ethyl acetate were used to dissolve the residue. The organic solution washed with water, dried (MgSO4) and the solvent removed to yield the title compound as a brown solid (58.4 g).

1. temperatureat reflux for 7 hours
2. temperatureThe reaction was cooled
3. customthe methanol removed
4. customThe residue was partitioned between ethyl acetate and water
5. dissolutionto dissolve the residue
6. washThe organic solution washed with water
7. dry with materialdried (MgSO4)
8. customthe solvent removed