反应详情

A mixture of methyl 2-{2-amino-1-[(methyloxy)carbonyl]ethenyl}-1-methyl-1H-pyrrole-3-carboxylate (2 g) and sodium t-butoxide (160 mg) in dimethylformamide (18 ml) was irradiated within a microwave reactor at 160° C. for 20 minutes. The reaction was repeated 28 times. The reaction mixtures were combined (56.4 g) and after cooling a precipitate formed which was filtered, washed with water and dried in vacuo to yield the title compound (17.1 g).

1. customwas irradiated within a microwave reactor at 160° C. for 20 minutes
2. customThe reaction mixtures
3. temperatureafter cooling a precipitate
4. customformed which
5. filtrationwas filtered
6. washwashed with water
7. customdried in vacuo