3,5-Difluoroaniline → HCID 57840950, compound

HRID 733704Notes

Reaction equation

HRID 733704 reaction equation
C(OC([N:8]1[C:12]2=[C:13](Cl)[N:14]=[CH:15][C:16]([C:17](=[O:23])[NH:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[C:11]2[C:10]([CH3:25])=[CH:9]1)=O)(C)(C)C.[F:26][C:27]1[CH:28]=[C:29]([CH:31]=[C:32]([F:34])[CH:33]=1)[NH2:30]>C(OCC)C>[C:19]([NH:18][C:17]([C:16]1[C:11]2[C:10]([CH3:25])=[CH:9][NH:8][C:12]=2[C:13]([NH:30][C:29]2[CH:28]=[C:27]([F:26])[CH:33]=[C:32]([F:34])[CH:31]=2)=[N:14][CH:15]=1)=[O:23])([CH3:20])([CH3:21])[CH3:22]

Participants

4

Reactant 2

HCID 965953,5-DifluoroanilineHCID 57840951HCID 57840951, compound

Product 1

HCID 57840950HCID 57840950, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Prepared in a similar manner to Example 4(d) from 4-tert-butylcarbamoyl-7-chloro-3-methyl-pyrrolo[2,3-c]pyridine-1-carboxylic acid ter-butyl ester (68 mg) and using 3,5-difluoroaniline (38 ul) instead of 3-bromoaniline. Isolated by MDAP rather than trituration with diethyl ether to give the title compound (28 mg).

Sources & evidence

ORD record
ord-5ef0b24c683e4bce84c74521f0ef3277
Source dataset
uspto-grants-2009_09
Patent number
US07589206B2

Reaction notes

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