Hydrochloric Acid → N-(3-Chlorophenyl)-1-ethyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-amine hydrochloride

HRID 733748Notes

Reaction equation

HRID 733748 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:14]3[CH:15]=[CH:16][N:17]([CH2:18][CH3:19])[C:13]=3[C:12]([C:20]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[O:21])=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:14]3[CH:15]=[CH:16][N:17]([CH2:18][CH3:19])[C:13]=3[C:12]([C:20]([N:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)=[O:21])=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11581787N-(3-Chlorophenyl)-1-ethyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-amine

Product 1

HCID 68868579N-(3-Chlorophenyl)-1-ethyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-amine hydrochlorideYield 117.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

N-(3-Chlorophenyl)-1-ethyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-amine (14 mg) was dissolved in diethyl ether (2 ml) and 2M hydrochloric acid solution in diethyl ether added to give a solid precipitate. The diethyl ether was decanted off and the solid dried by evaporation to afford the title compound as a white powder (9 mg).

Workup

  1. customto give a solid precipitate
  2. customThe diethyl ether was decanted off
  3. customthe solid dried by evaporation

Sources & evidence

ORD record
ord-27996acc54fa4d12b6b759e09a2792a6
Source dataset
uspto-grants-2009_09
Patent number
US07589206B2

Reaction notes

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