Benzene, ((2-bromoethoxy)methyl)- → 5-Fluoropyrimidine-2,4-diamine

HRID 733900Notes

Reaction equation

HRID 733900 reaction equation
NC1C=C([NH:8][C:9]2[N:14]=[C:13]([NH:15]C3C=CC=C(N)C=3)[C:12]([F:23])=[CH:11][N:10]=2)C=CC=1.C(OCCBr)C1C=CC=CC=1>>[F:23][C:12]1[C:13]([NH2:15])=[N:14][C:9]([NH2:8])=[N:10][CH:11]=1

Participants

3

Reactant 2

HCID 73833Benzene, ((2-bromoethoxy)methyl)-HCID 10215022N2,N4-bis(3-aminophenyl)-5-fluoro-2,4-primidinediamine

Product 1

HCID 2556085-Fluoropyrimidine-2,4-diamine

Procedure

In like manner to the preparation of N2,N4-bis(3-tert-butoxycarbonylmethyleneaminophenyl)-5-fluoro-2,4-pyrimidinediamine, N2,N4-bis(3-aminophenyl)-5-fluoro-2,4-pyrimidinediamine and 1-benzyloxy-2-bromoethane were reacted together to give N2,N4-bis[3-N-benzyloxyethyleneamino)phenyl]-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 32.92 min.; MS (m/e): 579.17 (MH+).

Workup

  1. customwere reacted together

Sources & evidence

ORD record
ord-2f18ac869c594e81b1d22cf1162e74ea
Source dataset
uspto-grants-2009_09
Patent number
US07589200B2

Reaction notes

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