反应详情

A solution of 6-hydroxymethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine (330 mg) in dichloromethane (30 mL)/THF (30 mL) was treated with manganese dioxide (730 mg) and stirred at room temperature. Further manganese dioxide was added after 1 h (730 mg) and 16 h (300 mg). After a total of 20 h the mixture was filtered through kieselguhr and the filtrate evaporated. The product was triturated with EtOAc/hexane (1:1) and collected to give a solid (180 mg); LC/MS (APCI−) m/z 195 ([M−H]−, 95%), 165 (100%).

1. filtrationAfter a total of 20 h the mixture was filtered through kieselguhr
2. customthe filtrate evaporated
3. customThe product was triturated with EtOAc/hexane (1:1)
4. customcollected