1,1'-Carbonyldiimidazole → HCID 66673986, compound

HRID 73424Notes

Reaction equation

HRID 73424 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[I:17])[C:5]([NH2:18])=[C:4]([O:19][CH3:20])[CH:3]=1.[C:21](N1C=CN=C1)(N1C=CN=C1)=[O:22]>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([O:19][CH3:20])[C:5]2[NH:18][C:21](=[O:22])[N:9]([C:10]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=3[I:17])[C:6]=2[C:7]=1[F:8]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 86618900HCID 86618900, compound

Product 1

HCID 66673986HCID 66673986, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the stirred solution of 5,6-difluoro-N1-(4-fluoro-2-iodophenyl)-3-methoxybenzene-1,2-diamine (0.17 gm, 0.43 mmol) in CH2Cl2 (2 ml), 1,1′-Carbonyldiimidazole (0.085 gm, 0.53 mmol) was added. This reaction mixture was kept stirring at room temperature for 16 hours when product precipitated out. The white solid was filtered and used further without any purification. (0.089 gm); m/z=419 [M−1]−.

Workup

  1. customprecipitated out
  2. filtrationThe white solid was filtered
  3. customused further without any purification

Sources & evidence

ORD record
ord-f88f9f913de54ecea463a122884320bc
Source dataset
uspto-grants-2014_09
Patent number
US08829052B2

Reaction notes

Loading…