4-Bromoaniline → 2-[2-(4-bromophenyl)-2H-tetrazol-5-yl]pyridine

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Reaction Steps

Following the procedure described in EXAMPLE 1 for the synthesis of 1-methyl-3-[3-(5-pyridin-2-yl-2H-tetrazol- 2-yl)phenyl]imidazolidin-2-one, but using 4-bromoaniline (17.2 g, 100 mmol) and pyridine-2-carboxaldehyde (10.7 g, 100 mmol), 2-[2-(4-bromophenyl)-2H-tetrazol-5-yl]pyridine was obtained as an orange solid. 1H-NMR (CDCl3, 300 MHz) δ 8.83 (d, 1H), 8.33 (d, 1H), 8.15 (d, 2H), 7.96-7.87 (m, 1H), 7.70 (d, 2H), 7.44 (dd, 1H).

Provenance & Evidence