反应详情

Following the procedure described in EXAMPLE 1 for the synthesis of 1-methyl-3-[3-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]imidazolidin-2-one, but using 3-iodoaniline (11 g, 50 mmol) and pyridine-2-carboxaldehyde (4.7 mL, 50 mmol), 2-[2-(3-iodophenyl)-2H-tetrazol-5-yl]pyridine was obtained as a biege solid. 1H-NMR (CDCl3, 300 MH) δ NMR 8.92 (d, 1H), 8.69 (m, 1H), 8.44 (d, 1H), 8.30 (d, 1H), 8.03-8.06 (m, 1H), 7.87-7.88 (m, 1H), 7.56-7.59 (m, 1H), 7.32-7.35 (m, 1H).