Thionyl Chloride → HCID 86760961, compound

HRID 734348Notes

Reaction equation

HRID 734348 reaction equation
[ClH:1].[CH:2]([N:5]1[CH2:10][CH2:9][N:8]([C:11]([CH:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([OH:27])=O)=[CH:21][CH:20]=3)[CH2:15][CH2:14]2)=[O:12])[CH2:7][CH2:6]1)([CH3:4])[CH3:3].S(Cl)([Cl:30])=O>>[ClH:30].[CH:2]([N:5]1[CH2:10][CH2:9][N:8]([C:11]([CH:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([Cl:1])=[O:27])=[CH:21][C:20]=3[Cl:30])[CH2:15][CH2:14]2)=[O:12])[CH2:7][CH2:6]1)([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 68817423HCID 68817423, compound

Product 1

HCID 86760961HCID 86760961, compound

Procedure

1-Isopropyl4-[1-(4-carboxy-phenyl)-piperidin-4-carbonyl]-piperazine hydrochloride (D9) (0.25 g) was dissolved in thionyl chloride (10 ml) and heated at reflux for 1.5 h. The reaction mixture was then evaporated to a minimum (co-evaporated with DCM, 3×10 ml) to give the subtitled compound as a yellow oil (0.25 g).

Workup

  1. temperatureheated
  2. temperatureat reflux for 1.5 h
  3. customThe reaction mixture was then evaporated to a minimum (co-evaporated with DCM, 3×10 ml)

Sources & evidence

ORD record
ord-2f519eae86a044eb93b9af1f149b8856
Source dataset
uspto-grants-2009_09
Patent number
US07592347B2

Reaction notes

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