Thionyl Chloride → HCID 86760961, compound

Participants

Reaction Steps

1-Isopropyl4-[1-(4-carboxy-phenyl)-piperidin-4-carbonyl]-piperazine hydrochloride (D9) (0.25 g) was dissolved in thionyl chloride (10 ml) and heated at reflux for 1.5 h. The reaction mixture was then evaporated to a minimum (co-evaporated with DCM, 3×10 ml) to give the subtitled compound as a yellow oil (0.25 g).

Provenance & Evidence