3-(2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline → 3-{2-[4-(7-Chloro-2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

HRID 734503Notes

Reaction equation

HRID 734503 reaction equation
CC1C=CC2C(=CC=CC=2N2CCN(CCC3C=C(C=CC=3)N)CC2)N=1.[Cl:27][C:28]1[CH:37]=[C:36]2[C:31]([CH:32]=[CH:33][C:34]([CH3:38])=[N:35]2)=[C:30]([N:39]2[CH2:44][CH2:43][N:42]([CH2:45][CH2:46][C:47]3[CH:52]=[CH:51][CH:50]=[C:49]([N+:53]([O-])=O)[CH:48]=3)[CH2:41][CH2:40]2)[CH:29]=1>>[Cl:27][C:28]1[CH:37]=[C:36]2[C:31]([CH:32]=[CH:33][C:34]([CH3:38])=[N:35]2)=[C:30]([N:39]2[CH2:40][CH2:41][N:42]([CH2:45][CH2:46][C:47]3[CH:48]=[C:49]([CH:50]=[CH:51][CH:52]=3)[NH2:53])[CH2:43][CH2:44]2)[CH:29]=1

Participants

3

Reactant 2

HCID 498521053-(2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}anilineHCID 574442767-Chloro-2-methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline

Product 1

HCID 574443093-{2-[4-(7-Chloro-2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}anilineYield 92%

Procedure

The title compound was prepared in 92% yield using a similar procedure to description D6 starting from 7-Chloro-2-methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline (D17).

Sources & evidence

ORD record
ord-22e46e6eb61f4aa88f5588dd4d5bea74
Source dataset
uspto-grants-2009_09
Patent number
US07592346B2

Reaction notes

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