Sulfuric Acid → HCID 68428065, compound

HRID 734541Notes

Reaction equation

HRID 734541 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]3[CH:21]=[C:22]([N:26]4[CH2:30][CH2:29][NH:28][C:27]4=[O:31])[CH:23]=[CH:24][CH:25]=3)[CH2:14][CH2:13]2)[N:3]=1.[S:32](=[O:36])(=[O:35])([OH:34])[OH:33]>CO>[S:32]([OH:36])([OH:35])(=[O:34])=[O:33].[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]3[CH:21]=[C:22]([N:26]4[CH2:30][CH2:29][NH:28][C:27]4=[O:31])[CH:23]=[CH:24][CH:25]=3)[CH2:14][CH2:13]2)[N:3]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 11292933Gsk163090

Product 1

HCID 68428065HCID 68428065, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (300 mg, 1 wt) is suspended in methanol (6.0 ml, 20 vol) at room temperature under nitrogen. A solution of sulfuric acid (71 mg, 1 eq) in methanol is dosed. The clear solution is seeded and solid crystallization is observed. The slurry is stirred 16 hrs at room temperature. The solid is filtered and dried at room temperature under vacuum to give the desired salt.

Workup

  1. customsolid crystallization
  2. filtrationThe solid is filtered
  3. customdried at room temperature under vacuum

Sources & evidence

ORD record
ord-4046ebdc3ce045a9bad43228971ae716
Source dataset
uspto-grants-2009_09
Patent number
US07592346B2

Reaction notes

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