Ammonia → 2,2,2-Trifluoro-1-(piperidin-4-yl)ethan-1-one

HRID 734766Notes

Reaction equation

HRID 734766 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]([CH:5]1[CH2:10][CH2:9][N:8](C(OCC2C=CC=CC=2)=O)[CH2:7][CH2:6]1)=[O:4].N>CCOC(C)=O.CO>[F:22][C:2]([F:1])([F:21])[C:3]([CH:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)=[O:4]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 69063371HCID 69063371, compound

Product 1

HCID 452576622,2,2-Trifluoro-1-(piperidin-4-yl)ethan-1-one

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

The product was obtained analogously to IP 2b starting from 900 mg (2.85 mmol) of benzyl 4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate. Yield: 516 mg (quant. yield); C7H10F3NO (M=181.156); calc.: molpeak (M+H)+: 182; found: molpeak (M+H)+: 182; Rf value: 0.18 (silica gel, EtOAc/MeOH/conc. aqueous ammonia 5:5:0.5).

Sources & evidence

ORD record
ord-45bdd2ec25c9489d999cfe04a7e5feb5
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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