HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2,2,2-Trifluoro-1-(piperidin-4-yl)ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 69063371 | HCID 69063371 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | 2,2,2-Trifluoro-1-(piperidin-4-yl)ethan-1-one | HCID 45257662 | — |
Reaction Steps
The product was obtained analogously to IP 2b starting from 900 mg (2.85 mmol) of benzyl 4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate. Yield: 516 mg (quant. yield); C7H10F3NO (M=181.156); calc.: molpeak (M+H)+: 182; found: molpeak (M+H)+: 182; Rf value: 0.18 (silica gel, EtOAc/MeOH/conc. aqueous ammonia 5:5:0.5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-45bdd2ec25c9489d999cfe04a7e5feb5 |
| Source note | uspto-grants-2009_09 |