Ammonia → HCID 57845325, compound

HRID 734772Notes

Reaction equation

HRID 734772 reaction equation
C([N:8]1[CH2:13][CH2:12][C@:11]([C:15]([F:18])([F:17])[F:16])([OH:14])[C@H:10]([OH:19])[CH2:9]1)C1C=CC=CC=1.N>CCOC(C)=O.CO>[F:18][C:15]([F:16])([F:17])[C@:11]1([OH:14])[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]1[OH:19]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 69058240HCID 69058240, compound

Product 1

HCID 57845325HCID 57845325, compound

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

The product was obtained analogously to intermediate product IP 5d starting from (3R,4S)-1-benzyl-4-trifluoromethylpiperidin-3,4-diol. Yield: 665 mg (91% of theoretical); C6H10F3NO2 (M=185.144); calc.: molpeak (M+H)+: 186; found: molpeak (M+H)+: 186; Rf value: 0.35 (silica gel, EtOAc/MeOH/conc. aqueous ammonia 7:3:0.3).

Sources & evidence

ORD record
ord-f9dcad55e6c2433f813e2d28377aec44
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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