HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 57845325, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 69058240 | HCID 69058240 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | HCID 57845325 | HCID 57845325 | — |
Reaction Steps
The product was obtained analogously to intermediate product IP 5d starting from (3R,4S)-1-benzyl-4-trifluoromethylpiperidin-3,4-diol. Yield: 665 mg (91% of theoretical); C6H10F3NO2 (M=185.144); calc.: molpeak (M+H)+: 186; found: molpeak (M+H)+: 186; Rf value: 0.35 (silica gel, EtOAc/MeOH/conc. aqueous ammonia 7:3:0.3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-f9dcad55e6c2433f813e2d28377aec44 |
| Source note | uspto-grants-2009_09 |