Ethyl acetate methanol ammonia → 4-Isopropylpiperidin-4-ol

HRID 734785Notes

Reaction equation

HRID 734785 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([CH:15]([CH3:17])[CH3:16])([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.CCOC(C)=O.CO.N>>[CH:15]([C:11]1([OH:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 21873639Ethyl acetate methanol ammoniaHCID 690614431-Benzyl-4-isopropylpiperidin-4-ol

Product 1

HCID 574162904-Isopropylpiperidin-4-ol

Procedure

The product was obtained analogously to Example IP 5d from 9.85 g (42.2 mmol) of 1-benzyl-4-isopropylpiperidin-4-ol. Yield: 1.13 g (19% of theoretical); C8H17NO (M=143.227); calc.: molpeak (M+H)+: 144; found: molpeak (M+H)+: 144; Rf value: 0.07 (silica gel, EtOAc/MeOH/NH3 5:5:0.5).

Sources & evidence

ORD record
ord-0508f6b455694593bf5756569bcc7b1f
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

Loading…