2-(4-Trimethylsilanylethynylphenoxy)ethanol → 2-(4-Ethynylphenoxy)ethan-1-ol

HRID 734794Notes

Reaction equation

HRID 734794 reaction equation
C[Si]([C:5]#[C:6][C:7]1[CH:16]=[CH:15][C:10]([O:11][CH2:12][CH2:13][OH:14])=[CH:9][CH:8]=1)(C)C>CCOC(C)=O>[C:6]([C:7]1[CH:16]=[CH:15][C:10]([O:11][CH2:12][CH2:13][OH:14])=[CH:9][CH:8]=1)#[CH:5]

Participants

3

Reactant 1

HCID 684733242-(4-Trimethylsilanylethynylphenoxy)ethanol

Product 1

HCID 187514152-(4-Ethynylphenoxy)ethan-1-ol

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The product was obtained analogously to Example 1.1c starting from 12.20 g (52.05 mmol) of 2-(4-trimethylsilanylethynylphenoxy)ethanol. Yield: 7.70 g (91% of theoretical); C1oH10O2 (M=162.185); calc.: molpeak (M+H)+: 163; found: molpeak (M+H)+: 163; Rf value: 0.32 (silica gel, PE/EtOAc 6:4).

Workup

  1. customThe product was obtained analogously to Example 1.1c

Sources & evidence

ORD record
ord-b9bf8cfa3087477f85ba7aa4218b9f46
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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