HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dibromopyridine → 2-[4-(5-Bromopyridin-2-ylethynyl)phenoxy]ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dibromopyridine | HCID 69353 | — |
| Reactant | 2-(4-Ethynylphenoxy)ethan-1-ol | HCID 18751415 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-[4-(5-Bromopyridin-2-ylethynyl)phenoxy]ethanol | HCID 69060371 | — |
Reaction Steps
The product was obtained analogously to Example 1.1d starting from 7.70 g (47.48 mmol) of 2-(4-ethynylphenoxy)ethanol and 11.37 g (48.00 mmol) of 2,5-dibromopyridine. Yield: 7.40 g (49% of theoretical); C15H12BrNO2 (M=318.165); calc.: molpeak (M+H)+: 318/320 (Br); found: molpeak (M+H)+: 318/320 (Br); Rf value: 0.20 (silica gel, PE/EtOAc 6:4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-3f2a23d8988d4ff2af1bb25f218aabd2 |
| Source note | uspto-grants-2009_09 |