Cyclopropanemethanamine → HCID 69065035, compound

HRID 734796Notes

Reaction equation

HRID 734796 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]#[C:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)=[CH:19][N:18]=2)=[CH:11][CH:10]=1)(=O)=O.[CH:30]1([CH2:33][NH2:34])[CH2:32][CH2:31]1>>[Cl:29][C:26]1[CH:27]=[CH:28][C:23]([C:20]2[CH:21]=[CH:22][C:17]([C:16]#[C:15][C:12]3[CH:13]=[CH:14][C:9]([O:8][CH2:7][CH2:6][NH:34][CH2:33][CH:30]4[CH2:32][CH2:31]4)=[CH:10][CH:11]=3)=[N:18][CH:19]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 86601132HCID 86601132, compound

Product 1

HCID 69065035HCID 69065035, compound

Procedure

The product was obtained analogously to Example 4.1f starting from 2-{4-[5-(4-chlorophenyl)pyridin-2-ylethynyl]phenoxy}ethyl methanesulfonate (Example 4.1e) and C-cyclopropylmethylamine. Yield: 700 mg (43% of theoretical); C25H23ClN2O (M=402.916); calc.: molpeak (M+H)+: 403/405 (Cl); found: molpeak (M+H)+: 403/405 (Cl); HPLC-MS: 5.08 minutes (method B).

Workup

  1. customThe product was obtained analogously to Example 4.1f
  2. custom5.08 minutes (method B)

Sources & evidence

ORD record
ord-38c9395fe713429bbdcb2941dbf5c02e
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

Loading…