HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Iodo-2-methyl-phenoxy)-ethanol → 2-{4-[5-(4-Chlorophenyl)-3-fluoropyridin-2-ylethynyl]-2-methylphenoxy}ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Iodo-2-methyl-phenoxy)-ethanol | HCID 4055115 | — |
| Reactant | 5-(4-Chlorophenyl)-2-ethynyl-3-fluoropyridine | HCID 60055416 | — |
| Product | 2-{4-[5-(4-Chlorophenyl)-3-fluoropyridin-2-ylethynyl]-2-methylphenoxy}ethanol | HCID 69061948 | — |
Reaction Steps
The product was obtained analogously to Example 7.1e starting from 2-(4-iodo-2-methylphenoxy)ethanol and 5-(4-chlorophenyl)-2-ethynyl-3-fluoropyridine. Yield: 1.40 g (68% of theoretical); C22H17ClFNO2 (M=381.827); calc.: molpeak (M+H)+: 382/384 (Cl); found: molpeak (M+H)+: 382/384 (Cl); HPLC-MS: 6.29 minutes (method B).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-603da89f22f945e2ad28d9de4eebd354 |
| Source note | uspto-grants-2009_09 |