5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 69064853, compound

HRID 734807Notes

Reaction equation

HRID 734807 reaction equation
I[C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][OH:9])=[C:4]([CH:12]=[CH2:13])[CH:3]=1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:22]=[CH:23][C:24]([C:27]#[CH:28])=[N:25][CH:26]=2)=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[CH:22]=[CH:23][C:24]([C:27]#[C:28][C:2]3[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][OH:9])=[C:4]([CH:12]=[CH2:13])[CH:3]=3)=[N:25][CH:26]=2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69059991HCID 69059991, compound

Product 1

HCID 69064853HCID 69064853, compound

Procedure

The product was obtained analogously to Example 7.1e starting from 2-(4-iodo-2-vinylphenoxy)ethanol and 5-(4-chlorophenyl)-2-ethynylpyridine. Yield: 0.66 g (96% of theoretical); C23H18ClNO2 (M=375.847); calc.: molpeak (M+H)+: 376/378 (Cl); found: molpeak (M+H)+: 376/378 (Cl); HPLC-MS: 6.21 minutes (method B).

Workup

  1. customThe product was obtained analogously to Example 7.1e
  2. custom6.21 minutes (method B)

Sources & evidence

ORD record
ord-3a0f2790978d4358803775961e265534
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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