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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 734814Generated: October 30, 2026

Hydroxylamine → 5-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]-2-[2-(4-methylpiperidin-1-yl)ethoxy]benzaldehydeoxime

https://huagongshe.com/reaction/734814

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydroxylamineHCID 787—
ReactantHCID 86601135HCID 86601135—
Product5-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]-2-[2-(4-methylpiperidin-1-yl)ethoxy]benzaldehydeoximeHCID 72984184—

Reaction Steps

The product was obtained analogously to Example 14.1d starting from 5-[5-(4-chlorophenyl)pyridin-2-ylethynyl]-2-[2-(4-methylpiperidin-1-yl)ethoxy]benzaldehyde (Example 14.1c) and hydroxylamine. Yield: 40 mg (46% of theoretical); C28H28ClN3O2 (M=473.994); calc.: molpeak (M+H)+: 474/476 (Cl); found: molpeak (M+H)+: 474/476 (Cl); HPLC-MS: 5.68 minutes (method A).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07592358B2
Source datasetuspto-grants-2009_09
ORD IDord-ebc5bff40cb3472ea4478754608e7e73
Source noteuspto-grants-2009_09