BROMINE CHLORIDE (BrCl) → 3-Bromo-5-(4-chlorophenyl)-2-ethynylpyridine

HRID 734817Notes

Reaction equation

HRID 734817 reaction equation
[Br:1][C:2]1[C:3]([C:15]#[C:16][Si](C)(C)C)=[N:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:7]=1.BrCl>>[Br:1][C:2]1[C:3]([C:15]#[CH:16])=[N:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 61697BROMINE CHLORIDE (BrCl)2×HCID 69057764HCID 69057764, compound

Product 1

HCID 860770513-Bromo-5-(4-chlorophenyl)-2-ethynylpyridine

Procedure

The product was prepared analogously to Example 7.1d starting from 3-bromo-5-(4-chlorophenyl)-2-trimethylsilanylethynylpyridine. Yield: 0.44 g (55% of theoretical); C13H7BrClN (M=292.558); calc.: molpeak (M+H)+: 292/294/296 (BrCl); found: molpeak (M+H)+: 292/294/296 (BrCl); HPLC-MS: 6.21 minutes (method B).

Workup

  1. customThe product was prepared analogously to Example 7.1d
  2. custom6.21 minutes (method B)

Sources & evidence

ORD record
ord-1856f18b2f2840a2bf7cacf40ea1befb
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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