1-(2-(4-Iodophenoxy)ethyl)-4-methylpiperidine → 5-(4-Chlorophenyl)-2-{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridin-3-ylamine

Participants

Role	Name	HCID	Charge
Reactant	1-(2-(4-Iodophenoxy)ethyl)-4-methylpiperidine	HCID 69061017	—
Reactant	5-(4-Chlorophenyl)-2-ethynylpyridin-3-ylamine	HCID 86077060	—
Product	5-(4-Chlorophenyl)-2-{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridin-3-ylamine	HCID 11496018	—

Reaction Steps

The product was prepared analogously to Example 7.1e starting from 5-(4-chlorophenyl)-2-ethynylpyridin-3-ylamine and 1-[2-(4-iodophenoxy)ethyl]-4-methylpiperidine. Yield: 0.63 (75% of theoretical); C27H28ClN3O (M=445.984); calc.: molpeak (M+H)+: 446/448 (Cl); found: molpeak (M+H)+: 446/448 (Cl); HPLC-MS: 5.05 minutes (method D).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07592358B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-38c238e82e6c4a08b576ffd3d7fc397e
Source note	uspto-grants-2009_09