反应详情

温度

110 °C

73 mg (0.386 mmol) of CuI, 1.16 g (7.71 mmol) of NaI, and N,N′-dimethylethane-1,2-diamine were added under argon to a solution of 1.20 g (3.86 mmol) of (4-bromo-2-methylphenyl)-[2-(4-methylpiperidin-1-yl)ethyl]amine in 3.9 mL of 1,4-dioxane and the mixture was stirred for 20 hours at 110° C. The reaction mixture was cooled to RT and diluted with EtOAc. The organic phase was washed with 10% aqueous ammonia, dried over magnesium sulfate, and evaporated down in vacuo. Yield: 1.22 g (88% of theoretical); C15H23IN2 (M=358.261); calc.: molpeak (M+H)+: 359; found: molpeak (M+H)+: 359; HPLC-MS: 6.24 minutes (method A).

1. temperatureThe reaction mixture was cooled to RT
2. washThe organic phase was washed with 10% aqueous ammonia
3. dry with materialdried over magnesium sulfate
4. customevaporated down in vacuo
5. custom6.24 minutes (method A)