5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 57845334, compound

HRID 734850Notes

Reaction equation

HRID 734850 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[C:6]([CH:9]=1)[CH2:7][NH2:8].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[CH:32])=[N:29][CH:30]=2)=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[C:32][C:2]3[CH:3]=[CH:4][C:5]([O:10][CH2:11][CH2:12][N:13]4[CH2:17][CH2:16][CH2:15][CH2:14]4)=[C:6]([CH:9]=3)[CH2:7][NH2:8])=[N:29][CH:30]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69061391HCID 69061391, compound

Product 1

HCID 57845334HCID 57845334, compound

Procedure

The product was obtained analogously to Example 7.1e starting from 5-iodo-2-(2-pyrrolidin-1-ylethoxy)benzylamine and 5-(4-chlorophenyl)-2-ethynylpyridine. Yield: 28 mg (11% of theoretical); C26H26ClN3O (M=431.957); calc.: molpeak (M+H)+: 432/434 (Cl); found: molpeak (M+H)+: 432/434 (Cl); HPLC-MS: 3.90 minutes (method B).

Workup

  1. customThe product was obtained analogously to Example 7.1e
  2. custom3.90 minutes (method B)

Sources & evidence

ORD record
ord-3470fcb32d504ce68c19a92f8b97961e
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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