5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 57845309, compound

HRID 734858Notes

Reaction equation

HRID 734858 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([O:9][CH2:10][CH2:11][N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[C:6]([OH:8])[CH:7]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[CH:31])=[N:28][CH:29]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[C:31][C:2]3[CH:3]=[CH:4][C:5]([O:9][CH2:10][CH2:11][N:12]4[CH2:16][CH2:15][CH2:14][CH2:13]4)=[C:6]([OH:8])[CH:7]=3)=[N:28][CH:29]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69061413HCID 69061413, compound

Product 1

HCID 57845309HCID 57845309, compound

Procedure

The product was obtained analogously to Example 7.1e starting from 5-iodo-2-(2-pyrrolidin-1-ylethoxy)phenol and 5-(4-chlorophenyl)-2-ethynylpyridine. Yield: 0.75 g (48% of theoretical); C25H23ClN2O2 (M=418.915); calc.: molpeak (M+H)+: 419/421 (Cl); found: molpeak (M+H)+: 419/421 (Cl); HPLC-MS: 7.33 minutes (method A).

Workup

  1. customThe product was obtained analogously to Example 7.1e
  2. custom7.33 minutes (method A)

Sources & evidence

ORD record
ord-b1559f8104774836a3dce911a05f1fc1
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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