5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 69059110, compound

HRID 734861Notes

Reaction equation

HRID 734861 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][OH:11])=[N:6][CH:7]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]=[CH:21][C:22]([C:25]#[CH:26])=[N:23][CH:24]=2)=[CH:15][CH:14]=1>>[Cl:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:20]=[CH:21][C:22]([C:25]#[C:26][C:2]3[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][OH:11])=[N:6][CH:7]=3)=[N:23][CH:24]=2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69065025HCID 69065025, compound

Product 1

HCID 69059110HCID 69059110, compound

Procedure

The product was obtained analogously to Example 7.1e starting from 3-(5-iodopyridin-2-yl)propan-1-ol and 5-(4-chlorophenyl)-2-ethynylpyridine. Yield: 0.80 g (74% of theoretical); C21H17ClN2O (M=348.825); calc.: molpeak (M+H)+: 349/351 (Cl); found: molpeak (M+H)+: 349/351 (Cl); HPLC-MS: 8.24 minutes (method A).

Workup

  1. customThe product was obtained analogously to Example 7.1e
  2. custom8.24 minutes (method A)

Sources & evidence

ORD record
ord-93e3d3903fe44fcd8be0ebea738418bd
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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