1-Bromo-4-iodobenzene → HCID 69057479, compound

HRID 734864Notes

Reaction equation

HRID 734864 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:17]=[CH:18][C:19]([C:22]#[CH:23])=[N:20][CH:21]=2)=[CH:12][CH:11]=1.BrCl>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:23]#[C:22][C:19]2[CH:18]=[CH:17][C:16]([C:13]3[CH:14]=[CH:15][C:10]([Cl:9])=[CH:11][CH:12]=3)=[CH:21][N:20]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 115221-Bromo-4-iodobenzeneHCID 61697BROMINE CHLORIDE (BrCl)2×HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridine

Product 1

HCID 69057479HCID 69057479, compound

Procedure

The product was obtained analogously to Example 7.1e starting from 4-bromoiodobenzene and 5-(4-chlorophenyl)-2-ethynylpyridine. Yield: 7.10 g (90% of theoretical); C19H11BrClN (M=368.654); calc.: molpeak (M+H)+: 368/370/372 (BrCl); found: molpeak (M+H)+: 368/370/372 (BrCl); HPLC-MS: 7.60 minutes (method A).

Workup

  1. customThe product was obtained analogously to Example 7.1e
  2. custom7.60 minutes (method A)

Sources & evidence

ORD record
ord-37c3ca2b66094d86a383f3f7f36f1368
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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