1-(2-(4-Iodophenoxy)ethyl)-4-methylpiperidine → (5-(4-Chlorophenyl)-2-{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridin-3-yl)methylamine

Participants

Role	Name	HCID	Charge
Reactant	1-(2-(4-Iodophenoxy)ethyl)-4-methylpiperidine	HCID 69061017	—
Reactant	[5-(4-Chlorophenyl)-2-ethynylpyridin-3-yl]methylamine	HCID 86601138	—
Product	(5-(4-Chlorophenyl)-2-{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridin-3-yl)methylamine	HCID 69063344	—

Reaction Steps

The product was prepared analogously to Example 7.1e starting from 1-[2-(4-iodophenoxy)ethyl]-4-methylpiperidine and [5-(4-chlorophenyl)-2-ethynylpyridin-3-yl]methylamine. Yield: 70 mg (21% of theoretical); C28H30ClN3O (M=460.010); calc.: molpeak (M+H)+:460/462 (Cl); found: molpeak (M+H)+:460/462 (Cl); HPLC-MS: 5.30 minutes (method D).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07592358B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-707876839b944af5837fa74e9fff8fe3
Source note	uspto-grants-2009_09