反应详情

Under an argon atmosphere 9.38 mL (15.0 mmol, 1.6 M) of n-butyllithium was slowly added to a solution of 4.71 g (15.0 mmol) of 5-bromo-2-[(tert-butyldimethylsilanyl)ethynyl]-3-fluoropyridine in 100 mL of diethyl ether at −70° C., so that the internal temperature did not rise above −65° C. After 2 minutes, 1.84 mL (15.0 mmol) of 4-methylcyclohexanone was added and then the cooling bath was removed. The reaction solution was heated to RT and then combined with 50 mL of aqueous saturated ammonium chloride solution. The organic phase was separated off, the aqueous phase was extracted twice with MTBE, and the combined organic phases were dried over magnesium sulfate, filtered through activated charcoal, and the solvent was removed in vacuo. The residue was taken up in DIPE, cooled in the cooling bath, and the precipitate formed (1.4 g) was suction filtered. The mother liquor was concentrated in vacuo and the residue was purified by column chromatography (silica gel, PE/EtOAc 8:2). A further 2.1 g were obtained, which were combined with the above precipitate. The product was obtained as a cis/trans mixture. Yield: 3.50 g (67% of theoretical); C20H30FNOSi (M=347.542); calc.: molpeak (M+H)+:348; found: molpeak (M+H)+:348; Rf value: 0.5 (silica gel, PE/EtOAc 8:2).

1. customdid not rise above −65° C
2. customthe cooling bath was removed
3. customThe organic phase was separated off
4. extractionthe aqueous phase was extracted twice with MTBE
5. dry with materialthe combined organic phases were dried over magnesium sulfate
6. filtrationfiltered through activated charcoal
7. customthe solvent was removed in vacuo
8. temperaturecooled in the cooling bath
9. customthe precipitate formed (1.4 g)
10. filtrationfiltered
11. concentrationThe mother liquor was concentrated in vacuo
12. customthe residue was purified by column chromatography (silica gel, PE/EtOAc 8:2)
13. customA further 2.1 g were obtained
14. customThe product was obtained as a cis/trans mixture