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5-(4-Chlorophenyl)-2-iodopyridine → (5-{4-[5-(4-Chlorophenyl)pyridin-2-yl]but-3-ynyl}pyridin-2-yl)isopropylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(4-Chlorophenyl)-2-iodopyridine | HCID 85969849 | — |
| 反応物 | (5-But-3-ynylpyridin-2-yl)isopropylamine | HCID 86076998 | — |
| 生成物 | (5-{4-[5-(4-Chlorophenyl)pyridin-2-yl]but-3-ynyl}pyridin-2-yl)isopropylamine | HCID 57845312 | — |
反応手順
The product was prepared analogously to Example 50.5d from 100 mg (0.53 mmol) of (5-but-3-ynylpyridin-2-yl)isopropylamine and 168 mg (0.53 mmol) of 5-(4-chlorophenyl)-2-iodopyridine (purification by preparative HPLC-MS). Yield: 520 mg (54% of theoretical); C23H22ClN3 (M=375.894); calc.: molpeak (M+H)+:376/378; found: molpeak (M+H)+:376/378; HPLC-MS: 5.33 minutes (method G).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07592358B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-7c04f7a3d5aa44e5a1ccd4d1d0a95461 |
| 出典メモ | uspto-grants-2009_09 |