Trifluoroacetic acid → HCID 57843339, compound

HRID 734967Notes

Reaction equation

HRID 734967 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:17]=[C:16]3[C:11]([N:12]=[CH:13][C:14]([N:18]4[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]4)=[N:15]3)=[CH:10][CH:9]=2)=[CH:4][C:3]=1[NH:31][S:32]([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)(=[O:34])=[O:33].FC(F)(F)C(O)=O>C(#N)C>[Cl:1][C:2]1[C:3]([NH:31][S:32]([C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)(=[O:33])=[O:34])=[CH:4][C:5]([C:8]2[CH:17]=[C:16]3[C:11](=[CH:10][CH:9]=2)[N:12]=[CH:13][C:14]([N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)=[N:15]3)=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57843442HCID 57843442, compound

Product 1

HCID 57843339HCID 57843339, compoundYield 65.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 1,1-dimethylethyl 4-(7-{6-chloro-5-[(phenylsulfonyl)amino]-3-pyridinyl}-2-quinoxalinyl)-1-piperazinecarboxylate (0.83 mmol) in acetonitrile (6 ml) was added concentrated trifluoroacetic acid (3 ml). The reaction stirred at ambient temperature for 3 hours and was then concentrated to an orange oil. The residue was neutralized with saturated sodium bicarbonate solution upon which a precipitate was formed. The product was filtered and dried to give the title compound (260 mg, 65%) as an off-white solid. MS(ES)+ m/e 481.2 [M+H]+.

Workup

  1. concentrationwas then concentrated to an orange oil
  2. customwas formed
  3. filtrationThe product was filtered
  4. customdried

Sources & evidence

ORD record
ord-2091a7a7cf894cb788aaa0ee5189b4d4
Source dataset
uspto-grants-2009_09
Patent number
US07592342B2

Reaction notes

Loading…