Methanesulfonyl chloride → HCID 86601887, compound

HRID 735000Notes

Reaction equation

HRID 735000 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:26])[C:16]#[C:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][OH:25])=[CH:20][CH:19]=3)=[CH:10][CH:9]=2)=[C:4]([F:27])[CH:3]=1.[CH3:28][S:29](Cl)(=[O:31])=[O:30].ClCCl.CO.N>>[CH3:28][S:29]([O:25][CH2:24][C:21]1[CH:22]=[CH:23][C:18]([C:17]#[C:16][C:15](=[O:26])[NH:14][C:11]2[CH:12]=[CH:13][C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=3[F:27])=[CH:9][CH:10]=2)=[CH:19][CH:20]=1)(=[O:31])=[O:30]

Participants

4

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 21584172Ammonia methanol dichloromethaneHCID 68816802HCID 68816802, compound

Product 1

HCID 86601887HCID 86601887, compound

Procedure

Prepared analogously to Example 1.2.b. from 3-(4-hydroxymethylphenyl)propynoic acid-(4′-chloro-2′-fluorobiphenyl-4-yl)amide and methanesulfonic acid chloride. Yield: 0.23 g (50% of theory); C23H17ClFN2O2S (M=457.91); calc.: molecular ion peak (M+H)+: 456/458; found: molecular ion peak (M+H)+: 456/458; Rf value: 0.5 (silica gel, dichloromethane/methanol/ammonia (20:1:0.1)).

Workup

  1. customPrepared analogously to Example 1.2.b

Sources & evidence

ORD record
ord-0edd9e6007e6473bb943f6d97e927739
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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