4-(1-Pyrrolidinyl)piperidine → HCID 68816274, compound

HRID 735002Notes

Reaction equation

HRID 735002 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[N:10]1([CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[CH2:14][CH2:13][CH2:12][CH2:11]1>ClCCl.C(O)C>[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:18]2[CH2:19][CH2:20][CH:15]([N:10]3[CH2:14][CH2:13][CH2:12][CH2:11]3)[CH2:16][CH2:17]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 9542584-Iodobenzyl bromide

Product 1

HCID 68816274HCID 68816274, compound

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

Prepared analogously to Example 1.1.c. from 4-iodobenzyl bromide and 4-pyrrolidin-1-ylpiperidine. Yield: 0.57 g (51% of theory); C16H23IN2 (M=370.28); calc.: molecular ion peak (M+H)+: 371; found: molecular ion peak (M+H)+: 371; Rf value: 0.3 (silica gel, dichloromethane/ethanol (20:1)).

Workup

  1. customPrepared analogously to Example 1.1.c

Sources & evidence

ORD record
ord-5745d6df08134cf48749021b6f368408
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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