4-Iodobenzyl bromide → HCID 68816491, compound

HRID 735008Notes

Reaction equation

HRID 735008 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[NH:10]1[CH2:15][CH2:14][CH:13]([C:16]([OH:19])([CH3:18])[CH3:17])[CH2:12][CH2:11]1>ClCCl.C(O)C>[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:10]2[CH2:15][CH2:14][CH:13]([C:16]([OH:19])([CH3:18])[CH3:17])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9542584-Iodobenzyl bromideHCID 52003212-(4-Piperidyl)-2-propanol

Product 1

HCID 68816491HCID 68816491, compound

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

Prepared analogously to Example 1.1.c. from 4-iodobenzyl bromide and 2-piperidin-4-ylpropan-2-ol. Yield: 1.01 g (67% of theory); C15H22INO (M=359.25); calc.: molecular ion peak (M+H)+: 360; found: molecular ion peak (M+H)+: 360; Rf value: 0.4 (silica gel, dichloromethane/ethanol (20:1)).

Workup

  1. customPrepared analogously to Example 1.1.c

Sources & evidence

ORD record
ord-dc8c9874e1ef49db95941d1ff542cb25
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

Loading…