4-Methoxypiperidine → HCID 65478349, compound

HRID 735011Notes

Reaction equation

HRID 735011 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH3:10][O:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>ClCCl.C(O)C>[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:15]2[CH2:16][CH2:17][CH:12]([O:11][CH3:10])[CH2:13][CH2:14]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 776664-MethoxypiperidineHCID 9542584-Iodobenzyl bromide

Product 1

HCID 65478349HCID 65478349, compound

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

Prepared analogously to Example 1.1.c. from 4-iodobenzyl bromide and 4-methoxypiperidine. Yield: 0.93 g (66.7% of theory); C13H18INO (M=331.19); calc.: molecular ion peak (M+H)+: 332; found: molecular ion peak (M+H)+: 332; Rf value: 0.55 (silica gel, dichloromethane/ethanol (20:1)).

Workup

  1. customPrepared analogously to Example 1.1.c

Sources & evidence

ORD record
ord-0f2556df002744ce8325eb2589009294
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

Loading…