4-Iodobenzyl bromide → HCID 68816798, compound

HRID 735013Notes

Reaction equation

HRID 735013 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH3:10][C:11]1([OH:17])[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>ClCCl.C(O)C>[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:14]2[CH2:15][CH2:16][C:11]([CH3:10])([OH:17])[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9542584-Iodobenzyl bromideHCID 156491744-Methylpiperidin-4-ol

Product 1

HCID 68816798HCID 68816798, compound

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

Prepared analogously to Example 1.1.c. from 4-iodobenzyl bromide and 4-methylpiperidin-4-ol. Yield: 0.22 g (30% of theory); C13H18INO (M=331.19); calc.: molecular ion peak (M+H)+: 332; found: molecular ion peak (M+H)+: 332; Rf value: 0.45 (silica gel, dichloromethane/ethanol (20:1)).

Workup

  1. customPrepared analogously to Example 1.1.c

Sources & evidence

ORD record
ord-edab6f259c0e43d6bd37e16c6cd924f1
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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