Ffumobqylsjsfv-uhfffaoysa- → 3-[4-(2-Pyrrolidin-1-ylethyl)phenyl]propynoic acid-4-chlorophenylamide

HRID 735028Notes

Reaction equation

HRID 735028 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:12])[C:10]#[CH:11])=[CH:4][CH:3]=1.I[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][N:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)=[CH:16][CH:15]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:12])[C:10]#[C:11][C:14]2[CH:15]=[CH:16][C:17]([CH2:20][CH2:21][N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[CH:18][CH:19]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14491743Ffumobqylsjsfv-uhfffaoysa-HCID 688158361-(4-Iodophenethyl)pyrrolidine

Product 1

HCID 578457063-[4-(2-Pyrrolidin-1-ylethyl)phenyl]propynoic acid-4-chlorophenylamide

Procedure

Prepared analogously to Example 2.1.e. from propynoic acid-(4-chlorophenyl)amide and 1-[2-(4-iodophenyl)ethyl]pyrrolidine. Yield: 80 mg (34.1% of theory); melting point: 153° C.-154° C.; C21H21ClN2O (M=352.86); calc.: molecular ion peak (M+H)+: 353/355; found: molecular ion peak (M+H)+: 353/355.

Workup

  1. customPrepared analogously to Example 2.1.e

Sources & evidence

ORD record
ord-a4399676efbf44629d1a24b5d07ec496
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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