反应详情

6.27 mL of a 1M sodium hydroxide solution is added to a solution of 0.9 g (3.13 mmol) of ethyl (E)-3-(4′-chlorobiphenyl-4-yl)acrylate in 30 mL of ethanol and stirred for 3 hours at ambient temperature. The reaction is stopped by the addition of 6.27 mL of 1N hydrochloric acid and the reaction mixture is stirred for 2 hours. Then the mixture is evaporated down, the residue is combined with water, and the precipitate is filtered off. The precipitate is repeatedly rinsed with water and dried at 80° C. in the vacuum drying chamber. Yield: 0.68 g (67% of theory); C15H11ClO2 (M=258.70); calc.: molecular ion peak (M−H)−: 257/259; found: molecular ion peak (M−H)−: 257/259; Rf value: 0.5 (silica gel, dichloromethane/methanol (90:10)).

1. stirringthe reaction mixture is stirred for 2 hours
2. customThen the mixture is evaporated down
3. filtrationthe precipitate is filtered off
4. washThe precipitate is repeatedly rinsed with water
5. customdried at 80° C. in the vacuum
6. customdrying chamber