HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Piperidin-1-ylmethyl)aniline → (E)-3-(4'-chlorobiphenyl-4-yl)-N-(4-piperidin-1-ylmethylphenyl)acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Piperidin-1-ylmethyl)aniline | HCID 846150 | — |
| Reactant | (E)-3-(4'-chlorobiphenyl-4-yl)acrylic Acid | HCID 5957595 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | (E)-3-(4'-chlorobiphenyl-4-yl)-N-(4-piperidin-1-ylmethylphenyl)acrylamide | HCID 9980157 | — |
Reaction Steps
Prepared analogously to Example 3.1.e. from [(E)-3-(4′-chlorobiphenyl-4-yl)acrylic acid and 4-piperidin-1-ylmethylphenylamine. Yield: 0.57 g (62.9% of theory); melting point: 265° C.-270° C.; C27H27ClN2O (M=430.98); calc.: molecular ion peak (M+H)+: 431/433; found: molecular ion peak (M+H)+: 431/433; Rf value: 0.31 (silica gel, dichloromethane/methanol (90:10)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-9b99f17524c74ce083683e6ca8205c9e |
| Source note | uspto-grants-2009_09 |